PKM and breast carcinoma: In terms of mechanism, circ_0022382 could bind to let-7a-5p, it was reported that the down-regulated let-7a-5p in breast cancer could regulate the growth and progression of breast cancer cells, for example, the let-7a-5p/DUSP7 axis was associated with paclitaxel resistance (22), the let-7a-5p/GLUT12 axis (23) and the let-7a-5p/STAT3/hnRNP-A1/PKM2 axis (24) were associated with glycolysis in breast cancer.