A retrospective analysis involving 79 cases with BRCA mutations revealed that the most common structural domains of BRCA1 mutations in high-grade serous ovarian cancer (HGSC) were the BRCT (C-terminal) domain (15 cases, 31%) and the DNA Binding Domain (DBD) (13 cases, 27%). Here, BRCA1 is linked to ovarian serous adenocarcinoma.