SIRT4 and hepatocellular carcinoma: As results revealed, of 23 DE-LMRGs, 10 genes were associated with HCC prognosis, and 8 of them (NT5DC2, TXNRD1, MRPS23, AIFM2, ACACA, MRPL3, APOO, SIRT4) were associated with poor prognosis, and 2 of them (GCDH, ADHFE1) were associated with good prognosis (Figure 2H).