In the PVALB+ DLPFC:Inh10 subtype, the top significant change in cellular distributions, we observed a decrease in the number of these interneurons in the resilient group compared to controls (Figure S10H, adj-P = 0.02), suggesting that PVALB+ inhibitory neurons may be important for a distinct process of protection against AD, such as resistance to AD pathology. This evidence concerns the gene PVALB and Alzheimer disease.