We employ the Eμ-Myc mouse model19 and the P493–6 cell line20 to model the cellular response to supraphysiological Myc overexpression in B lymphocytes, we use splenic murine primary B lymphocytes activated with lipopolysaccharides (LPS) as a comparator to induce physiologically relevant enhanced levels of Myc expression, and we utilize the Burkitt’s lymphoma-derived CA46 and DG75 cell lines as models of bona fide Myc-dependent cancer cells. Here, MYC is linked to cancer.