PRPS1 and lymphoma: To test whether PRPS2 KO could counteract Myc’s role as global regulator of anabolic metabolism in bona fide models of fully transformed Myc-driven lymphoma, we measured total RNA content per cell (Fig. 4B), protein synthesis rates (Supplementary Fig. 4A), total protein per cell (Fig. 4C), average cell diameter (Fig. 4D) and mitochondrial mass (Fig. 4E), and observed no significant changes upon PRPS1 KO or PRPS2 KO in CA46 and DG75 cells.