To assess the requirement of Myc-driven, PRPS-dependent redox regulation in the context of fully transformed B cell lymphoma, we generated single-cell selected CRISPR/Cas9 knockouts of both PRPS1 and PRPS2 in CA46 and DG75 Burkitt’s lymphoma-derived cell lines (Fig. 3A). Here, MSMB is linked to Burkitt lymphoma.