APOE and Alzheimer disease: This hypothesis is integrated into our unifying model [15, 16] implicating peroxidation of ApoE-containing lipoproteins, with consequent ApoE receptor-ligand disruption and compromised ApoE receptor 2-Disabled homolog-1 (ApoER2-Dab1) pathway function, as the initiating molecular events that ultimately lead to AD in humans.