ApoE and ApoJ also accumulate together with Aβ in cerebral amyloid angiopathy lesions.[17] The human brain and glia-derived brain lipoproteins are enriched in dozens of polyunsaturated fatty acid (PUFA)-containing lipid species [2–4] that are highly vulnerable to peroxidation;[18] extensive brain lipid peroxidation has been reported even in the earliest stages of mild cognitive impairment (MCI) and AD [19, 20] (reviewed in [15]). This evidence concerns the gene APOE and Alzheimer disease.