,30 It is worth noting that numerous other neural crest lineages that also require migration do so normally in Edn3 and Ednrb mutants and in other WS models (e.g., dorsal root and sympathetic chain ganglia, the outflow tract of the heart, adrenal medulla, etc.), so impaired migration of stria intermediate cells in Edn3 or Ednrb mutants is not a foregone conclusion. This evidence concerns the gene EDNRB and Werner syndrome.