Among the top five genes ranked in the GRS risk model, MAN1A1 (44, 45), DERL3 (46), CHST1 (47), and HS6ST3 (48) have all been reported for their roles in BC, whereas the role of LMAN1L in various cancers, especially TNBC, has not been investigated. Here, MAN1A1 is linked to breast cancer.