Besides, PAM (an polysaccharide of atractylodes macrocephala), enhances phagocytosis of CRC cells by bone marrow-derived macrophages (BMDM) through MyD88/TLR4-dependent signaling pathway and promotes the production of pro-inflammatory factors (e.g., IL-6, IFN-λ, and TNF-α) when combined with IFN-λ in CRC. The gene discussed is TNF; the disease is colorectal carcinoma.