Type 2 cytokines, including IL-4, IL-13, and IL-31; keratinocyte-derived TSLP and IL-33; and type 2 immune cells, including Eos, BS, MC, and Th2 cells, along with elevated serum IgE levels, play critical roles in the pathogenesis of AD and ACD (2, 4, 21, 31, 32). The gene discussed is IGHE; the disease is granular corneal dystrophy type II.