Concurrently, in rheumatoid arthritis (RA), CD8+ T cell subsets overexpress lactate dehydrogenase A (LDHA), and targeting LDHA activity to remodel glucose and glutamine metabolism in RA CD8+ T cells can mitigate the inflammatory and destructive role of these cells in the progression of autoimmune diseases (31). The gene discussed is LDHA; the disease is rheumatoid arthritis.