CFD and acute myeloid leukemia: In AML cells, both the PI3K/Akt and JAK/STAT signaling pathways were relatively highly expressed, showing a strong correlation with CFD. Following the induction of high CFD gene expression, JAK/STAT and PI3K/Akt pathways were simultaneously activated, with JAK/STAT exhibiting a more pronounced increase (Table 3, Figure 6C).