Of note, a recent study performed molecular testing on a subset of pediatric patients diagnosed with JXG. The results showed that five out of eight patients (62.5%) with pulmonary involvement carried the ALK translocation. In contrast, the above molecular alterations were not detected in patients with skin-only occurrence. This conclusion suggests that pathologists should not distinguish JXG from APH only by the presence or absence of ALK translocation, but also by the age of the patient, the location of the disease. JXG’s morphology and ALK negativity aid in distinguishing it from APH (17). Here, ALK is linked to juvenile xanthogranuloma.