Previous research revealed that CXCL6 can enhance the growth and metastases of ESCC cells through activating STAT3/PD-L1 pathway (69); on the other hand, the CXCL6 secretion by breast cancer cells induced by Ionizing radiation that can recruit antitumor effector T cells, convert tumors into relatively “inflamed” peripheral tissues, and improve the effect of immunotherapy (70). This evidence concerns the gene CXCL6 and esophageal squamous cell carcinoma.