AFP and neoplasm: Additionally, the prognosis for infiltrative HCC is worse compared to other subtypes (7), with poorer survival linked to compromised liver function (e.g., Child-Pugh score, Model for End-Stage Liver Disease score, and albumin-bilirubin grade) and higher tumor burden (e.g., elevated alpha-fetoprotein levels, vascular invasion, and extensive tumor size, number, or distribution) (5–9).