To detect the genes regulated by these CpGs that might involve in AD, we retrieved the annotation information of the CpGs from the Infinium MethylationEPIC Array (Fig. 2A), and cg11916609 was annotated in the transcriptional start sites (TSS) of IL1RL1 while cg10636246 was annotated in the TSS of AIM2 (Fig. 2A). This evidence concerns the gene IL1RL1 and Alzheimer disease.