Yet, interestingly regarding IL-6 levels, patients 1 and 2 with the highest levels and the highest depression scores, showed clear reductions after eight weeks treatment; patient 1 showed a reduction of IL-6 from 5.9 to 4.7 pg/L and patient 2 from 11.0 to 7.3 pg/L (Supplementary Table 4). This evidence concerns the gene IL6 and major depressive disorder.