Type of depression measure (ADS-L, BDI, POMS-TD) showed a statistically significant moderating effect on the relationship between depression level and concentration of IL-10 PHA (QM(2) = 6.93, p = .031), particularly for BDI (estimate = −0.69, p = .011) and not POMS-TD (estimate = −0.32, p = .248). This evidence concerns the gene IL10 and major depressive disorder.