It has been suggested that IL-10 levels increase initially in response to acute inflammation as part of the immune system response connected with depression with IL-10 levels eventually decreasing over the course of depression (Wiener et al., 2019; Chi et al., 2021; Al-Fadhel et al., 2019; Roque et al., 2009). The gene discussed is IL10; the disease is depressive symptom measurement.