USP6 and neoplasm: The TSC2 gene is mapped to chromosome 16p13.3 and contains 42 exons.4 The protein product encoded by the TSC2 gene, known as tuberin, could form a functional complex containing hamartin, tuberin, and Tre2-Bub2-Cdc16-1 domain family member 7, which serves as a critical inhibitor of tumor growth.