Malnutrition is a common complication in ESRD undergoing blood purification, and considered an important risk factor for mortality.25 Previous research show that long-term inflammatory state has a detrimental effect on protein metabolism, leading to malnutrition, while malnutrition can in turn exacerbate the degree of inflammatory response.26 In this study, levels of Hb, Alb, and SF in the hybrid group after the treatment were higher than those in the hemodialysis group. Here, ALB is linked to nutritional deficiency disease.