The prophylactic blood transfusion has a dual beneficial effect; this regime attains a sufficient Hb level to comply with the pregnancy needs and reduces the amount of HbS decreasing the chances of SCD-related vaso-occlusive complications.13 Still the clinical assessment of the SCD patient, co-morbidities, past treatment record, and complications history are important factors in deciding the blood transfusion modality during pregnancy. This evidence concerns the gene GSTM1 and Schnyder corneal dystrophy.