Several studies have revealed the harmful roles of NOX1/2-mediated oxidative stress in hypertension, including but not limited to the inactivation of NO and the production of peroxynitrite (Drummond et al., 2011; Drummond and Sobey, 2014; Matsuno et al., 2005; Murdoch et al., 2011). The gene discussed is NOX1; the disease is hypertensive disorder.