GPX4 and breast carcinoma: Moreover, a recent study demonstrated that Boswellia carterii n-hexane extract (BCHE) significantly inhibited the viability of human breast cancer cells and displayed potent in vivo anti-breast cancer activity without notable toxicity, inducing ferroptosis by upregulating transferrin expression and intracellular Fe2+ levels, downregulating glutathione peroxidase 4 (GPX4), and promoting ROS mediated lipid peroxidation in both breast cancer cells and tumor-bearing mice, suggesting BCHE as a potential therapeutic candidate for ferroptosis-targeted breast cancer treatment (Xie et al., 2024).