IFNG and rheumatoid arthritis: Perucha et al. [32] reported that Th1 cells treated with statins switched from a pro-inflammatory (IFN-γ+) to anti-inflammatory (IL-10+) phenotype, and the cholesterol biosynthesis pathway was blocked in rheumatoid arthritis (RA), indicating that cholesterol biosynthesis was required for the pro-inflammatory function of Th1 cells.