In this study, we found that pri-miR-192-5p was increased in CD4+T cells isolated from the peripheral blood of asthmatic children and sh-METTL3 reduced mature miR-192-5p expression by inhibiting the processing of pri-miR-192-5p in an m6A-dependent manner; thus, we speculated that METTL3 promoted the processing of pri-miR-192-5p into mature miR-192-5p to target SCD1 in CD4+T cells in asthma. Here, CD4 is linked to asthma.