Given its role in mediating homotypic and heterotypic cell interactions, ICAM-1 expression by melanoma cells mediates CD8+ T-cell melanoma cell lysis, regulates the formation of melanoma–CD8+ T cell–lymph node aggregates, and is superior to the BRAF/NRAS alteration status in predicting response to MAPKi (Hamaï et al, 2008; Krisp et al, 2018; Menares et al, 2019; Straetemans et al, 2015; Yanguas et al, 2018). The gene discussed is ICAM1; the disease is melanoma.