GP regulates glucose and lipid metabolism disorders, IR, oxidative stress, and anti-inflammatory responses; It improves intestinal microbiota dysbiosis, and regulates glycogen synthesis, gluconeogenesis, and glucose transport by activating the IRS-1/PI3K/Akt and AMPK signalling pathways, and improves IR by inhibiting the mitochondrial apoptosis signalling pathway. The gene discussed is IRS1; the disease is Disorder of lipid metabolism.