Notably, compounding walnut peptide with ginseng saponin to feed senescence-accelerated mice (SAM) revealed that walnut peptide significantly increased the serum levels of antioxidant enzymes and reduced Aβ and p-tau in the hippocampus through activation of the brain-derived neurotrophic factor (BDNF)/TrkB-dependent PI3K/Akt signalling pathway, significantly improving the memory of rats with neurodegenerative disease capacity (118). This evidence concerns the gene BDNF and neurodegenerative disease.