These data support a model in which SFN inhibits mTORC1 (Figure 2D), leading to activation of the EGR1 and TFEB transcription factors to induce autophagy and the CLEAR transcriptional program for lysosome biogenesis (Figure 3), extending previous studies of SFN-promoted autophagic flux (40) and induction of the CLEAR network in HeLa, Hep2G, and 1,321 N1 human astrocytoma cells (43). Here, TFEB is linked to astrocytoma (excluding glioblastoma).