PTPRR and neoplasm: Surgery is almost always recommended for PTPR after the pathologic diagnosis is confirmed and based on the available literature, is the most evidence-based intervention [7,9]. After surgery, adjuvant radiotherapy (RT) is also usually given despite the lack of evidence of benefit and most often consists of external beam radiotherapy to the tumor bed and macroscopic disease with doses of 45-59.4 Gy in 1.8-2 Gy once daily fractions [7,9,14-20].