Also supporting the view of large protein complexes as potential indicators of inflammatory activity, large protein complexes of proteins other than CD18 were reported to form in blood and synovial fluid (SF) from systemic lupus erythematosus (SLE) and RA patients, respectively [[14], [15], [16]] with clear connection to the level of pathological inflammation. This evidence concerns the gene ITGB2 and rheumatoid arthritis.