ASPSCR1 and Alzheimer disease: While ASPSCR1 was significantly less expressed in individuals with no to mild to severe cognitive impairment in the setting of general AD pathology (group 1 vs 2 vs 3), eight subpopulations of excitatory neurons were downregulated in participants with mild cognitive impairment versus none when considering one’s amyloid burden and six subpopulations when considering neuritic plaque burden (Table 5).