While ASPSCR1 was significantly less expressed in individuals with no to mild to severe cognitive impairment in the setting of general AD pathology (group 1 vs 2 vs 3), eight subpopulations of excitatory neurons were downregulated in participants with mild cognitive impairment versus none when considering one’s amyloid burden and six subpopulations when considering neuritic plaque burden (Table 5). This evidence concerns the gene ASPSCR1 and Cognitive impairment.