PSEN1 and Alzheimer disease: The second locus within the ZFYVE1 gene, encoding Zinc Finger FYVE Domain-containing Protein 1, resides 138 kb from the early-onset familial AD gene, presenilin 1 (PSEN1), and the lead variant had a genome-wide significant p-value of 6.7 * 10−10 (Table 1).