The VPS35 missense variant of uncertain significance p.Met607Val (16:46662991:T, rs1555523076, CADD=21.5, PrimateAI=0.81, AlphaMissense=0.18) was identified in a male PD patient of African ancestry in the NPDR Network dataset, while the p.Asp205His variant (16:46679050:C, CADD=29.4, PrimateAI=0.90, AlphaMissense=0.94) was identified in a male patient of African admixed ancestry in the GP2-BLAAC PD dataset (Table 3). The gene discussed is VPS35; the disease is Parkinson disease.