GBA1 and Parkinson disease: Lastly, a frameshift variant, GBA1 p.Ala300Profs*4 (1:155237441:GC:G, CADD=28.7), was identified in an early-onset female case of African genetic ancestry from the GP2-BLAAC PD dataset, who presented with initial PD symptoms in her early 40s and had a second-degree relative affected by the disease.