GBA1 and Parkinson disease: The second novel missense GBA1 p.Ile407Ser variant (1:155236249:A:C, rs1057519358, CADD=26.5, PrimateAI=0.66, AlphaMissense=0.81) was identified in a male patient of African admixed genetic ancestry from the GP2-BLAAC PD cohort with disease onset in his early 50s.