CD34 and medical procedure: The ESCaPE-CMD (Autologous CD34 cell therapy for thetreatment of coronary microvascular dysfunction in patients with angina andnonobstructive coronary arteries) [99] and the IMPROvE-CED (Intracoronary CD34+Cell Therapy for Treatment of Coronary Endothelial Dysfunction in Patients withAngina and Nonobstructive Coronary Arteries) [100] trials showed a significantreduction in angina episodes and need for nitrate therapy as well as an increasein CFR after intracoronary infusion of CD34+ stem cells.