WhileCIMT is an established marker for subclinical atherosclerosis, other modalities,such as coronary calcification, should also be considered in future studies.Although albuminuria is an established marker of renal involvement, the use ofadditional sensitive markers, such as microalbuminuria or cystatin C, in patientswith hypertension could verify our current results. This evidence concerns the gene CST3 and hypertensive disorder.