There are two main mutations in the homeostatic iron regulator (HFE) gene implicated in developing hemochromatosis, namely, the cysteine-to-tyrosine substitution at amino acid 282 (C282Y) and histidine-to-aspartic acid substitution at 63 (H63D) [1]. The gene discussed is HFE; the disease is hemochromatosis type 1.