RA: rheumatoid Arthritis; MTX: methotrexate; ACR: American College of Rheumatology; DAS28: Disease Activity Score in 28 joints; hsCRP: high-sensitivity C-reactive protein; CRP: C-reactive protein; HAQ-DI: Health Assessment Questionnaire-Disability Index; sc: subcutaneous; q: each; wk: week; NR: not reported; PBO: placebo; vs: versus; pts: patients; cDMARD: conventional disease-modifying antirheumatic drugs. This evidence concerns the gene CRP and rheumatoid arthritis.