The median values of CD4+ cell count were also correlated significantly (p = 0.02). Another study conducted in South Africa by Arendorf et al. [13] demonstrated that 60.4% of patients had at least one oral lesion, with 37.8% candidosis, 19.7% oral hairy leukoplakia, and 8.5% HIV-related periodontal disease. This evidence concerns the gene CD4 and candidiasis.