Adolescents who reported feeling more depressed and alone had a higher HbA1c. HbA1c was significantly inversely correlated with parents’ perceptions of T1DM treatment goals. Adolescents had decreased physical activity levels and made changes in diet and insulin requirements. Parents’ perceptions of diet and insulin changes during the lockdown were significantly associated with HbA1c. The gene discussed is INS; the disease is type 1 diabetes mellitus.