Negative regulators of bone metabolism (IL-6, TNF-α, IL-8, RANKL) were significantly higher in the DM/HG group. HbA1c < 10% did not compromise implant survival, but worsened PD and MBL were seen with increasing HbA1c levels in a dose-response manner. The gene discussed is CXCL8; the disease is Parkinson disease.