AGEs: Advanced Glycation End Products; BOP%: Bleeding on Probing Percentage; CI: Confidence Interval; DM/HG: Diabetes Mellitus/Hyperglycemia; DRMA: Dose-Response Meta-Analysis; HbA1c: Hemoglobin A1c; IL: Immediately Loaded; IL-6: Interleukin-6; IL-8: Interleukin-8; ISQ: Implant Stability Quotient; MBL: Marginal Bone Loss; MD: Mean Difference; PD: Probing Depth; PICF: Peri-Implant Crevicular Fluid; PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RANKL: Receptor Activator of Nuclear Factor Kappa-Β Ligand; RR: Relative Risk; TNF-α: Tumor Necrosis Factor Alpha. The gene discussed is TNFSF11; the disease is diabetes mellitus.