Given the significance of these biomarkers in the clinical management of COVID-19, this study aimed to evaluate the effects of B. coagulans Unique IS-2 and B. clausii UBBC-07 on the levels of CRP, serum ferritin, LDH, D-dimer, and IL-6 in COVID-19 patients and on recovery. The gene discussed is CRP; the disease is COVID-19.