T lymphocytes expressing NKG2D are present in the foci of chronic inflammatory diseases, such as active skin lesions in vitiligo, intestinal epithelium in CeD, intestinal lamina propria in CD, and synovial membrane in RA, and are associated with the production of inflammatory mediators (Ogasawara et al., 2004; Babic and Romagnani, 2018; Jacquemin et al., 2020). Here, KLRK1 is linked to cranioectodermal dysplasia.