ATXN3 and limb-girdle muscular dystrophy: As shown in venn diagram (Figure 6), following metabolic sub-pathways were identified as commonly altered in various forms of MDs and SCAs; Tryptophan metabolism in DMD, LGMD, SCA1, SCA3; Leucine- Valine metabolism in BMD and SCA3; Glutamate metabolism in DMD and SCA2; Glycosis- Pyruate metabolism in DMD and BMD; Gamma- Glut metabolism in DMD and LGMD.