CD28 and infection: Age > 60, a clinical factor associated with the TLT subtype, was associated with 57 upregulated genes, including BCR signaling genes, IL6 (related to infection), and IL21R (different from TLT vs. ME), and 141 downregulated genes including EPCAM, AR, WT1, and CD28 (Supplementary Fig. 1C, Supplementary Table 4).