To evaluate the potential impact of autoimmune disease on human naïve CD4+ T cell transcriptional heterogeneity, we analyzed filtered naïve CD4+ T cells from 4 adult (aSLE) and 27 pediatric (pSLE) lupus patients and matched healthy controls (5 aHD and 11 cHD) (Fig. 6A) (Nehar-Belaid et al., 2020). This evidence concerns the gene CD4 and autoimmune disease.