SH2B3 and inflammatory bowel disease: However, the story is not that simple, as there does not appear to be a clear “global genetic risk for autoimmunity”: The rs3184504 variant in the SH2B3 locus offers a good illustration, as its risk allele “T” was found associated with increased risk of celiac disease, IBD, MS, psoriasis, lupus, T1D and thyroiditis.