SH2B3 and rheumatoid arthritis: Figure 3D presents the same results in a more granular form, where we filtered the MS risk variants that showed genome-wide significance in at least one of the 24 phenotypes utilized here: for example, the rs3184504-T allele in the SH2B3 locus consistently shows increased risk in MS, lupus, celiac disease, thyroiditis, psoriasis, RA, and IBD (Supplementary table S4).