Moreover, DDX21 expression (HR: 1.734, 95% CI: 1.073–2.801, p=0.025) and BCLC stage (HR: 3.480, 95% CI: 2.132–5.682, p < 0.001) were independent risk factors for recurrence-free survival in HCC patients. The gene discussed is DDX21; the disease is hepatocellular carcinoma.