The regulation of lamin A in cells occurs both transcriptionally and post‐translationally, either by modulating the processing rate of prelamin A or by altering the phosporylation of lamin A. Drugs that affect LMNA gene expression, such as ATM inhibitors, or those that impair prelamin A processing, such as statins (which impact prelamin A farnesylation), or Akt inhibitors (which reduce lamin A Ser22 phosphorylation required for nuclear lamina disassembly), have proven effective in reducing cancer cell proliferation, migration, and overall tumor progression.149, 159, 160, 288, 289. The gene discussed is ATM; the disease is cancer.