Starting with the discovery of emerin, in 1994, and lamin A/C, the main constituent of the lamina, in 1999, as genetic determinants of Emery–Dreifuss muscular dystrophy, hundreds of mutations in LMNA and other genes encoding NE proteins emerged as the cause of various genetic diseases collectively known as laminopathies.15, 16, 17. Here, ELANE is linked to laminopathy.