In addition, blocking TSP1 can also mitigate renal interstitial fibrosis through the TSP1/CD47 signaling pathway, and ameliorate high glucose‐induced peritoneal fibrosis via downregulation of TGF‐β1/Smad3 signaling pathway.157, 158. The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.