The water-soluble probe, synthesized using click chemistry to combine IR820, GPC3 peptide, and DOTA-Gd, is employed for PTT/PDT and dual-modality imaging using fluorescence imaging (FLI) and magnetic resonance imaging (MRI) to guide surgical resection, effectively inhibiting mid- to late-stage HCC. This evidence concerns the gene GPC3 and hepatocellular carcinoma.