Duration of HIV infection (OR=0.576, 95%CI:0.444-0.747), albumin (OR=0.956, 95%CI:0.936, 0.976) and CD4+T cell counts (OR=0.999, 95%CI: 0.998,1.000) showed negative associations with opportunistic infections (P<0.05). Here, ALB is linked to HIV infectious disease.