As a result, it is thought that inhibiting the VEGF/VEGFR signaling pathway is a promising therapeutic target for controlling tumor angiogenesis and preventing potentially subsequent tumor growth (Vayner and Ball, 2000; Tugues et al., 2011; Eldehna et al., 2015; Abou-Seri et al., 2016). This evidence concerns the gene KDR and neoplasm.